Systemic argyria

J Clin Pathol. 1994 Jun;47(6):556-7. doi: 10.1136/jcp.47.6.556.


A 74 year old man presented with signs and symptoms of mild cardiac failure. His face and chest were severely discoloured, which was thought to be due to cyanosis. He deteriorated and died of bronchopneumonia. At post mortem examination multiple organs, including the skin, showed silver pigment deposition; he also had a gastric malignant neuroendocrine tumour. He gave no history of contact with silver compounds. Systemic argyria caused by chronic ingestion of silver compounds is a rare condition which, apart from its cosmetic effects, is thought to be relatively harmless; it is not thought to be carcinogenic. This condition can pose diagnostic problems for both clinicians and pathologists.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / complications
  • Aged
  • Argyria / complications
  • Argyria / pathology*
  • Esophageal Neoplasms / complications
  • Fatal Outcome
  • Humans
  • Kidney Glomerulus / pathology*
  • Liver Neoplasms / complications
  • Liver Neoplasms / secondary
  • Male
  • Neuroendocrine Tumors / complications
  • Neuroendocrine Tumors / pathology*
  • Stomach Neoplasms / complications
  • Stomach Neoplasms / pathology*