Methotrexate in systemic lupus erythematosus

J Rheumatol. 1994 May;21(5):836-8.


Objective: Methotrexate (MTX) has been used successfully in the treatment of rheumatoid arthritis, psoriatic arthritis, polymyositis, and Reiter's syndrome. Our objective was to determine the effectiveness of MTX in the treatment of systemic lupus erythematosus (SLE).

Methods: We reviewed retrospectively MTX therapy in 5 patients with SLE, 3 with renal disease and 2 with arthritis.

Results: MTX therapy was well tolerated and effective in all 5 patients.

Conclusion: MTX appears to be both effective and well tolerated in patients with SLE.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Arthritis / drug therapy
  • Arthritis / etiology
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / drug therapy*
  • Lupus Nephritis / drug therapy
  • Lupus Nephritis / etiology
  • Methotrexate / therapeutic use*
  • Retrospective Studies
  • Treatment Outcome


  • Methotrexate