Effects of exygen-nitrogen (1:1) at 760 Torr on the life span and fine structure of Drosophila melanogaster

Mech Ageing Dev. Jan-Feb 1975;4(1):41-57. doi: 10.1016/0047-6374(75)90006-8.

Abstract

Exposure of Drosophila melanogaster adult males to an atmosphere of O2-N2 (1:1) at 760 Torr resulted in a marked reduction of life span. Among the fine structural changes occurring in the oxygen-poisoned flies, the following were similar to age-related changes: ceroid-lipofuscin accumulation in the visceral organs, sponginess of the brain and accumulation of lamellated dense bodies in the nerve cells. Also, the oxygen-poisoned flies showed a loss of the cytoplasmic membranes of the sperm cells, an alteration which was previously found in y-irradiated, but not in normal senescent, flies. In our opinion, oxygen poisoning of Drosophila may provide a valid model of accelerated aging, at least in regard to peroxidation injury of cell organelles and ceroid-lipofuscin accumulation.

MeSH terms

  • Aging
  • Animals
  • Atmospheric Pressure
  • Brain / ultrastructure
  • Drosophila melanogaster / drug effects*
  • Drosophila melanogaster / ultrastructure
  • Longevity / drug effects*
  • Male
  • Malpighian Tubules / ultrastructure
  • Microscopy, Electron
  • Models, Biological
  • Nitrogen / pharmacology*
  • Oxygen / poisoning*
  • Seminal Vesicles / ultrastructure
  • Testis / ultrastructure

Substances

  • Nitrogen
  • Oxygen