Abstract
The in vitro activities of furo[2,3b]quinoline and acridone alkaloids against Plasmodium falciparum were evaluated by an isotopic semimicrotest. A pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and 2-nitro substituents in the acridone nucleus improved the antimalarial activities of the compounds. These findings provide a clue for further chemical modifications.
MeSH terms
-
Acridines / isolation & purification
-
Acridines / pharmacology*
-
Alkaloids / isolation & purification
-
Alkaloids / pharmacology*
-
Animals
-
Antimalarials / isolation & purification
-
Antimalarials / pharmacology*
-
Chloroquine / pharmacology
-
Drug Resistance
-
Plants, Medicinal / chemistry
-
Plasmodium falciparum / drug effects*
-
Quinolones / isolation & purification
-
Quinolones / pharmacology*
Substances
-
Acridines
-
Alkaloids
-
Antimalarials
-
Quinolones
-
Chloroquine