Molecular characterization of the gene encoding high-level mupirocin resistance in Staphylococcus aureus J2870

J E Hodgson; S P Curnock; K G Dyke; R Morris; D R Sylvester; M S Gross

doi:10.1128/AAC.38.5.1205

Molecular characterization of the gene encoding high-level mupirocin resistance in Staphylococcus aureus J2870

Antimicrob Agents Chemother. 1994 May;38(5):1205-8. doi: 10.1128/AAC.38.5.1205.

Authors

J E Hodgson¹, S P Curnock, K G Dyke, R Morris, D R Sylvester, M S Gross

Affiliation

¹ Department of Biotechnology, SmithKline Beecham Pharmaceuticals, Brockham Park, Betchworth Surrey, United Kingdom.

Abstract

The nucleotide sequence of the ileS gene conferring high-level resistance to mupirocin in Staphylococcus aureus J2870 has been determined. The gene sequence is substantially different from that of the native ileS gene of S. aureus, indicating that high-level resistance to mupirocin results from the acquisition of a novel ileS gene.

MeSH terms

Base Sequence
Cloning, Molecular
Codon
DNA, Bacterial / analysis
Drug Resistance, Microbial
Molecular Sequence Data
Mupirocin / pharmacology*
Open Reading Frames
RNA, Transfer, Ile / metabolism
Sequence Homology, Nucleic Acid
Staphylococcus aureus / drug effects*
Staphylococcus aureus / genetics*

Substances

Codon
DNA, Bacterial
RNA, Transfer, Ile
Mupirocin

Associated data

GENBANK/X75439