NF-ATp: A Transcription Factor Required for the Co-Ordinate Induction of Several Cytokine Genes

Immunol Today. 1994 Jun;15(6):274-81. doi: 10.1016/0167-5699(94)90007-8.

Abstract

The transcription factor NF-ATp is a target in activated T cells for the calcium-regulated phosphatase calcineurin, and is therefore a secondary target for the immunosuppressive drugs cyclosporin A and FK506. Here, Anjana Rao describes how NF-ATp cooperates with Fos- and Jun-family proteins to mediate transcription of the interleukin 2 gene, and how it may participate in the calcium-dependent transcription of other cytokine genes in several types of immune-system cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Cytokines / genetics*
  • Cytokines / metabolism
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Gene Expression Regulation
  • Genes, fos
  • Genes, jun
  • Molecular Sequence Data
  • NFATC Transcription Factors
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Phosphoproteins / genetics
  • Phosphoproteins / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Cytokines
  • DNA-Binding Proteins
  • NFATC Transcription Factors
  • Nuclear Proteins
  • Phosphoproteins
  • Transcription Factors