Phosphorylation and dephosphorylation of protein in regulating cellular function

J Pharmacol Toxicol Methods. 1994 Jun;31(3):135-9. doi: 10.1016/1056-8719(94)90075-2.


Phosphorylation state of cellular proteins reflects the balance between the activities of protein kinases and phosphoprotein phosphatases. The increase in cellular protein phosphorylation in response to stimuli can be achieved by either activating protein kinases and/or promoting the turnover of the protein phosphatases. This review will summarize current knowledge of the control of phosphorylation and dephosphorylation of protein in cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Mammals
  • Phosphoprotein Phosphatases / metabolism*
  • Phosphorylation
  • Protein Kinases / metabolism*
  • Proteins / metabolism*
  • Second Messenger Systems


  • Proteins
  • Protein Kinases
  • Phosphoprotein Phosphatases