Pleural effusion associated with chronic dantrolene administration

Ann Pharmacother. 1994 May;28(5):587-9. doi: 10.1177/106002809402800507.


Objective: To report a case of pleural effusion associated with chronic dantrolene administration.

Design: Case report.

Setting: Private, university-affiliated, teaching hospital.

Results: Twelve years after the initiation of low-dose dantrolene therapy for chronic spasticity, a 35-year-old man developed a pleural effusion with pleural and peripheral eosinophilia. This reaction gradually resolved over several months after discontinuation of the dantrolene therapy.

Conclusions: In patients treated with chronic dantrolene therapy, the presence of pleural effusions should raise the suspicion of dantrolene-induced disease. Withdrawal of dantrolene therapy has generally been associated with an alleviation of signs and symptoms within several months.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Dantrolene / administration & dosage
  • Dantrolene / adverse effects*
  • Eosinophilia / chemically induced*
  • Humans
  • Male
  • Pleural Effusion / chemically induced*
  • Time Factors


  • Dantrolene