Low catechol-O-methyltransferase activity in a Saami population

Eur J Clin Pharmacol. 1994;46(3):231-5. doi: 10.1007/BF00192554.


Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol hormones, neurotransmitters and certain drugs. It is subject to genetic polymorphism and ethnic differences. High red blood cell (RBC) COMT activity has been correlated with a poor response to levodopa treatment in Parkinson's disease. RBC COMT was determined in a Norwegian population (n = 213) of whom 115 were Saami (Laaps). The Saami had 16.5% lower RBC COMT activity compared to a non-Saami population sample from the northern part of Norway (n = 50), 13.9 vs. 16.4 units/ml RBC (U) (P = 0.04). This is the first report of any population with lower RBC COMT activity than a Caucasian population. A wide range of RBC COMT activities was found in the entire population examined (1.3-38.3 U).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Catechol O-Methyltransferase / blood
  • Catechol O-Methyltransferase / genetics*
  • Erythrocytes / enzymology
  • Ethnicity*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Norway
  • Polymorphism, Genetic
  • Sex Characteristics
  • Whites


  • Catechol O-Methyltransferase