Tec homology (TH) adjacent to the PH domain

FEBS Lett. 1994 Aug 22;350(2-3):263-5. doi: 10.1016/0014-5793(94)00783-7.


The pleckstrin homology (PH) domain is extended in the Btk kinase family by a region designated the TH (Tec homology) domain, which consists of about 80 residues preceding the SH3 domain. The TH domain contains a conserved 27 amino acid stretch designated the Btk motif and a proline-rich region. Sequence similarity was found to a putative Ras GTPase activating protein and a human interferon-gamma binding protein both in the PH domain and the Btk motif region. SLK1/SSP31 protein kinase and a non-catalytic p85 subunit of PI-3 kinase had similarity only with the proline rich region. The identification of a PH domain extension in some signal transduction proteins in different species suggests that this region is involved in protein-protein interactions.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agammaglobulinaemia Tyrosine Kinase
  • Amino Acid Sequence
  • Blood Proteins / chemistry
  • Consensus Sequence
  • Molecular Sequence Data
  • Multigene Family
  • Phosphoproteins*
  • Protein-Tyrosine Kinases / chemistry*
  • Sequence Alignment
  • Sequence Homology, Amino Acid


  • Blood Proteins
  • Phosphoproteins
  • platelet protein P47
  • Protein-Tyrosine Kinases
  • Agammaglobulinaemia Tyrosine Kinase
  • BTK protein, human