[Anticardiolipin syndrome with only skin involvement]

Hautarzt. 1994 Jun;45(6):394-7. doi: 10.1007/s001050050090.
[Article in German]

Abstract

In anticardiolipin syndrome (ACS) a typical antibody constellation is associated with thrombotic and hematologic disorders. Furthermore, recurrent abortion, cerebral ischemia and different skin disorders occur. We report the case of a 29-year-old female suffering for the first time from painful, necrotic deep ulcers on the upper and lower legs and livedo racemosa on the arms as a rare example of a merely cutaneous manifestation of ACS with no demonstrable underlying disease. After systemic treatment with high-dose methylprednisolone, azathioprin and hydrocolloid dressings, healing of the scar tissue occurred. Simultaneously, a maintenance dose of acetylsalicylic acid (100 mg/day) was administered. So far, neither cutaneous relapse nor other signs of ACS have occurred.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Antibodies, Anticardiolipin / analysis*
  • Antiphospholipid Syndrome / diagnosis*
  • Antiphospholipid Syndrome / drug therapy
  • Antiphospholipid Syndrome / pathology
  • Arm
  • Aspirin / administration & dosage
  • Azathioprine / administration & dosage
  • Combined Modality Therapy
  • Debridement
  • Drug Therapy, Combination
  • Female
  • Humans
  • Leg Dermatoses / diagnosis
  • Leg Dermatoses / drug therapy
  • Leg Dermatoses / pathology
  • Leg Ulcer / diagnosis
  • Leg Ulcer / drug therapy
  • Leg Ulcer / pathology
  • Methylprednisolone / administration & dosage
  • Necrosis
  • Skin / pathology

Substances

  • Antibodies, Anticardiolipin
  • Azathioprine
  • Aspirin
  • Methylprednisolone