Localized cervical lymphadenopathy induced by diphenylhydantoin sodium

Arch Otolaryngol. 1975 Jul;101(7):446-8. doi: 10.1001/archotol.1975.00780360046010.


Diphenylhydantoin sodium is a standard drug in the treatment of convulsive disorders. Numerous untoward reactions have been reported. Lymphadenopathy related to drug-induced hypersensitivity has occurred. A yound woman undergoing treatment for seizures developed a large, tender, localized neck mass, associated with trismus, spasmotic torticollis, fever, eosinophilia, and skin rash. She was thought to be suffering from a deep cervical fascial space abscess. Symptoms subsided rapidly after elimination of anticonvulsant medication.

MeSH terms

  • Adult
  • Cell Nucleus / ultrastructure
  • Cytoplasm / ultrastructure
  • Epilepsy, Tonic-Clonic / drug therapy
  • Female
  • Histiocytes / pathology
  • Humans
  • Lymph Nodes / pathology
  • Lymph Nodes / ultrastructure
  • Lymphatic Diseases / chemically induced*
  • Lymphatic Diseases / pathology
  • Phenytoin / adverse effects*
  • Phenytoin / therapeutic use


  • Phenytoin