Mutagenicity tests of polyoxyethylene hydrogenated castor oil 60 (HCO-60)

J Toxicol Sci. 1994 May;19(2):89-96. doi: 10.2131/jts.19.2_89.

Abstract

The genotoxicity of polyoxyethylene hydrogenated castor oil 60 (HCO-60) was examined in reverse mutation test in bacteria, chromosome aberration test in vitro and micronucleus test in mice. The in vitro tests were done with and without metabolic activation using rat liver microsomal fraction. HCO-60 did induce neither reverse mutation in Salmonella typhimurium TA100, TA98, TA1535, and TA1537 and in Escherichia coli WP2uvrA, nor chromosome aberrations in Chinese hamster V79 cells. In addition, no increase in micronucleated polychromatic erythrocytes was elicited in the bone marrow of BDF1 male and female mice. It is concluded that HCO-60 was not genotoxic in these in vitro and in vivo assays.

MeSH terms

  • Animals
  • Castor Oil / analogs & derivatives*
  • Castor Oil / toxicity
  • Chromosome Aberrations
  • Cricetinae
  • Cricetulus
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Female
  • Male
  • Mice
  • Mice, Inbred Strains
  • Micronucleus Tests
  • Mutagenesis / drug effects
  • Mutagenicity Tests
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / genetics
  • Surface-Active Agents / toxicity*

Substances

  • Surface-Active Agents
  • polyethoxylated castor oil
  • Castor Oil