Abstract
The authors studied feasibility of using flavours, particularly, agent M-1 containing basic nutrients of antipromotor action in available form and fish oil containing fatty omega-3 acids as well as natural vitamin E for correction of homeostasis in patients with gastrointestinal precancer. 142 patients at risk to develop gastrointestinal cancer received diets for 6 months by 2-month cycles: M-1 daily in a dose 15-50 g, fish oil in a dose 10-30 ml. Control subjects did not receive the diets. 6 months after the treatment start the test subjects exhibited regression of the disease in 36.6% the cases versus 14.1% in the controls. It is concluded that the above dietetic scheme promotes correction of antioxidant insufficiency and stabilization of cellular membranes in patients with mucosal dysplasia.
Publication types
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Clinical Trial
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English Abstract
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Randomized Controlled Trial
MeSH terms
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Antioxidants / pharmacology
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Antioxidants / therapeutic use*
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Cell Membrane / drug effects
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Chemical Industry*
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Fatty Acids, Omega-3 / pharmacology
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Fatty Acids, Omega-3 / therapeutic use
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Fish Oils / pharmacology
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Fish Oils / therapeutic use*
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Flavoproteins / pharmacology
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Flavoproteins / therapeutic use*
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Food, Fortified*
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Gastric Mucosa / drug effects
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Gastric Mucosa / pathology
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Gastrointestinal Neoplasms / epidemiology
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Gastrointestinal Neoplasms / pathology
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Gastrointestinal Neoplasms / prevention & control*
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Humans
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Occupational Exposure*
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Precancerous Conditions / therapy*
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Remission Induction
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Risk Factors
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Treatment Outcome
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Vitamin E / pharmacology
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Vitamin E / therapeutic use
Substances
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Antioxidants
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Fatty Acids, Omega-3
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Fish Oils
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Flavoproteins
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Vitamin E