[The role of diet in the prevention and treatment of precancerous conditions in the risk groups]

Vopr Pitan. Jul-Sep 1993;(4):41-4.
[Article in Russian]

Abstract

The authors studied feasibility of using flavours, particularly, agent M-1 containing basic nutrients of antipromotor action in available form and fish oil containing fatty omega-3 acids as well as natural vitamin E for correction of homeostasis in patients with gastrointestinal precancer. 142 patients at risk to develop gastrointestinal cancer received diets for 6 months by 2-month cycles: M-1 daily in a dose 15-50 g, fish oil in a dose 10-30 ml. Control subjects did not receive the diets. 6 months after the treatment start the test subjects exhibited regression of the disease in 36.6% the cases versus 14.1% in the controls. It is concluded that the above dietetic scheme promotes correction of antioxidant insufficiency and stabilization of cellular membranes in patients with mucosal dysplasia.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Cell Membrane / drug effects
  • Chemical Industry*
  • Fatty Acids, Omega-3 / pharmacology
  • Fatty Acids, Omega-3 / therapeutic use
  • Fish Oils / pharmacology
  • Fish Oils / therapeutic use*
  • Flavoproteins / pharmacology
  • Flavoproteins / therapeutic use*
  • Food, Fortified*
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / pathology
  • Gastrointestinal Neoplasms / epidemiology
  • Gastrointestinal Neoplasms / pathology
  • Gastrointestinal Neoplasms / prevention & control*
  • Humans
  • Occupational Exposure*
  • Precancerous Conditions / therapy*
  • Remission Induction
  • Risk Factors
  • Treatment Outcome
  • Vitamin E / pharmacology
  • Vitamin E / therapeutic use

Substances

  • Antioxidants
  • Fatty Acids, Omega-3
  • Fish Oils
  • Flavoproteins
  • Vitamin E