Psoriatic arthritis: a clinical, radiological and genetic study of 58 Italian patients

Acta Derm Venereol Suppl (Stockh). 1994;186:69-70.

Abstract

It is well known that genetic heterogeneity and/or the complex interaction of several MCH-linked risk factors can explain the onset and the broad spectrum of Psoriatic Arthritis (PsA) from the clinical point of view. Fifty-eight patients with PsA (Moll and Wright criteria), 35 men and 23 women, mean age of 45, 14, were studied; all the patients were assessed by both clinical and radiological examination, with particular attention to the sacroiliac joints. HLA typing of the patients confirmed the association between PsA and HLA-B39 (p = 0.0008) and Cw6 (p = 0.0011). In addition a significant increase in DQ2 antigen (p = 0.004) has been found. No correlation of any particular HLA antigen with clinical subsets (oligo-polyarticular peripheral PsA, axial PsA and axial with peripheral PsA) or erosive incidence of joint involvement-generally related to the duration of the disease--was found.

MeSH terms

  • Adult
  • Arthritis, Psoriatic* / diagnostic imaging
  • Arthritis, Psoriatic* / genetics
  • Arthritis, Psoriatic* / immunology
  • Arthritis, Psoriatic* / pathology
  • Female
  • HLA Antigens / analysis
  • Humans
  • Male
  • Middle Aged
  • Radiography

Substances

  • HLA Antigens