Magnetic resonance imaging in patients with sudden deafness

Acta Otolaryngol Suppl. 1994;514:32-6. doi: 10.3109/00016489409127554.


Although many theories on the etiology of sudden deafness have been proposed, the main pathological focus remains uncertain. In this study, MR examinations were performed on patients with unilateral sudden deafness to study the relationship between MRI findings and response to treatments, i.e. amidotrizoate, steroid, or both. In 7 out of 30 cases, the cochlea and/or the vestibule showed higher signal intensity on proton density and T2-weighted images on the diseased side (MRI positive cases). These findings suggest changes in the chemical composition of the perilymph and/or the endolymph, since proton density and T2-weighted images reflect water content. It appears that MRI positive sudden deafness is more difficult to cure even with the use of amidotrizoate or steroid than MRI negative sudden deafness. Amidotrizoate seems to be more effective in MRI negative sudden deafness. MRI would help us to further classify the etiology of sudden deafness.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Auditory Threshold / drug effects
  • Auditory Threshold / physiology
  • Cochlea / pathology
  • Contrast Media
  • Diatrizoate / administration & dosage
  • Diatrizoate / therapeutic use
  • Female
  • Follow-Up Studies
  • Gadolinium
  • Gadolinium DTPA
  • Hearing / drug effects
  • Hearing / physiology
  • Hearing Loss, Sudden / diagnosis*
  • Hearing Loss, Sudden / drug therapy
  • Hearing Loss, Sudden / etiology
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Organometallic Compounds
  • Pentetic Acid / analogs & derivatives
  • Perilymph
  • Steroids / administration & dosage
  • Steroids / therapeutic use
  • Vertigo / physiopathology
  • Vestibule, Labyrinth / pathology


  • Contrast Media
  • Organometallic Compounds
  • Steroids
  • Diatrizoate
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA