Human Prostate Cancer Cells: Inhibition of Proliferation by Vitamin D Analogs

Anticancer Res. May-Jun 1994;14(3A):1077-81.

Abstract

1,25-Dihydroxyvitamin D [1,25(OH)2D3, calcitriol] can inhibit the proliferation of some human prostate cancer cells but its clinical use is limited by hypercalcemia. We therefore explored the bioactivity of less calcemic vitamin D analogs. We studied the effects of calcitriol and 3 synthetic analogs at concentrations of 10(-6) to 10(-12) M on the in vitro proliferation of 3 human prostate carcinoma cell lines: DU 145, PC-3, and LNCaP. Calcitriol and analogs showed significant antiproliferative activity on PC-3 and LNCaP cells. DU 145 cells were inhibited by the analogs only. We conclude that vitamin D analogs warrant further investigation as therapeutic agents in prostate cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Calcitriol / pharmacology*
  • Cell Division / drug effects
  • Humans
  • Male
  • Prostatic Neoplasms / pathology*
  • Tumor Cells, Cultured
  • Vitamin D / pharmacology*
  • Vitamin D-Binding Protein / physiology

Substances

  • Vitamin D-Binding Protein
  • Vitamin D
  • Calcitriol