Severe episode of high fever with rash, lymphadenopathy, neutropenia, and eosinophilia after minocycline therapy for acne

Arch Intern Med. 1994 Sep 12;154(17):1983-4.


Minocycline is a tetracycline agent frequently used for acne therapy. It has a few rare but severe side effects that are not widely known but should be recognized early as drug related. These include acute hepatitis and liver failure; a Löffler-like syndrome with pulmonary infiltrates, wheezing, fever, and eosinophilia; skin eruptions, eosinophilic cellulitis, and pustular folliculitis with eosinophilia; and a lupuslike syndrome. Side effects that are better known and recognized include photosensitization, skin exanthema with pruritus, and pseudotumor cerebri.

Publication types

  • Case Reports

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Adult
  • Drug Eruptions / etiology*
  • Drug Hypersensitivity / etiology*
  • Eosinophilia / chemically induced*
  • Female
  • Fever / chemically induced*
  • Humans
  • Liver / enzymology
  • Lymphatic Diseases / chemically induced*
  • Minocycline / adverse effects*
  • Neutropenia / chemically induced*


  • Minocycline