A violation of the Swain-Scott principle, and not SN1 versus SN2 reaction mechanisms, explains why carcinogenic alkylating agents can form different proportions of adducts at oxygen versus nitrogen in DNA

Chem Res Toxicol. 1994 May-Jun;7(3):277-80. doi: 10.1021/tx00039a001.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkylating Agents / chemistry*
  • Carcinogens / chemistry*
  • DNA / chemistry*
  • DNA Damage*
  • Kinetics
  • Models, Chemical
  • Nitrogen / chemistry*
  • Nucleic Acid Conformation
  • Oxygen / chemistry*

Substances

  • Alkylating Agents
  • Carcinogens
  • DNA
  • Nitrogen
  • Oxygen