Characterization of the amyloid fibril from primary localized cutaneous nodular amyloidosis associated with Sjögren's syndrome

Dermatology. 1994;189(2):125-8. doi: 10.1159/000246814.


Background: Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare disease, and its pathogenesis of amyloid deposition is still unknown.

Objective: The purpose of this study was to know the origin of amyloid in PLCNA.

Methods: Water-soluble amyloid fibrils were isolated from the skin and resolved on SDS-PAGE, then subjected to immunoblot analysis.

Results: The major amyloid fibril protein was a 29-kD peptide which reacted with both anti-lambda- and anti-kappa-light-chain antibodies.

Conclusion: Amyloids in this particular case of PLCNA are derived from the polyclonal immunoglobulin light chain and some cases of PLCNA could be reactive diseases rather than neoplastic ones.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Amyloid / metabolism*
  • Amyloidosis / etiology
  • Amyloidosis / metabolism*
  • Amyloidosis / pathology
  • Biopsy
  • Female
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Sjogren's Syndrome / complications
  • Sjogren's Syndrome / metabolism*
  • Sjogren's Syndrome / pathology
  • Skin / pathology
  • Skin Diseases / etiology
  • Skin Diseases / metabolism*
  • Skin Diseases / pathology


  • Amyloid
  • amyloid protein AL