Potential diagnostic implications of breakpoints in the long arm of chromosome 8 in lipoblastoma

Cancer Genet Cytogenet. 1994 Aug;76(1):39-42. doi: 10.1016/0165-4608(94)90068-x.


We report a case of lipoblastoma in a 17-month-old male patient with a pseudodiploid karyotype of 46,XY,der(14)t(8;14)(q11.2;q24). The tumor cells show two normal chromosome 8 homologs in addition to the extra 8q11.2-->qter segment, making it trisomic for the region 8q11.2-->qter, and monosomic for 14q24-->qter. Reports of chromosome studies in lipoblastoma are rare; however, a breakpoint in the long arm of chromosome 8q11-13 appears to be emerging as a consistent finding.

Publication types

  • Case Reports

MeSH terms

  • Chromosome Aberrations*
  • Chromosomes, Human, Pair 8*
  • Humans
  • Infant
  • Karyotyping
  • Lipoma / genetics*
  • Lipoma / pathology
  • Male
  • Pelvic Neoplasms / genetics*
  • Pelvic Neoplasms / pathology