Prevention of recurrent aphthous stomatitis with colchicine: an open trial

J Am Acad Dermatol. 1994 Sep;31(3 Pt 1):459-61. doi: 10.1016/s0190-9622(94)70211-x.


Background: Recurrent aphthous stomatitis (RAS) is a common disorder with hitherto unsatisfactory drug therapy.

Objective: Our purpose was to evaluate the prophylactic effect of colchicine in the treatment of RAS.

Methods: An open, prospective, 4-month study was conducted in 20 patients with RAS who served as their own controls. During the first 2 months of the study no medications were given and in the last 2 months colchicine, 1.5 mg/day, was prescribed.

Results: The mean number of aphthae per week and the subjective daily pain scores were reduced by 71% and 77%, respectively, during colchicine treatment as compared with the previous period (p < 0.001 for both). No serious side effects of colchicine were noted.

Conclusion: These findings suggest a role for continuous colchicine therapy in the prevention of RAS.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Colchicine / adverse effects
  • Colchicine / therapeutic use*
  • Female
  • Humans
  • Male
  • Pilot Projects
  • Prospective Studies
  • Recurrence
  • Stomatitis, Aphthous / pathology
  • Stomatitis, Aphthous / prevention & control*


  • Colchicine