Hepatitis A and evidence against the community dissemination of Helicobacter pylori via feces

J Infect Dis. 1994 Sep;170(3):686-9. doi: 10.1093/infdis/170.3.686.

Abstract

Seroprevalence data from 1501 subjects was used to test the hypothesis that Helicobacter pylori may be transmitted by the fecal-oral route. Antibody to hepatitis A virus was used as a marker of fecal-oral exposure. Of the 1501 subjects, 35.5% were seropositive for both H. pylori and hepatitis A, 19.1% were seronegative for both, 36.5% were seropositive for hepatitis A only, and 8.8% were seropositive for H. pylori only. Cross-sectional data from rural areas supported an association between hepatitis A and H. pylori. However, in the urban area there was no evidence of hepatitis A infection in persons < 10 years old, yet the seroprevalence of H. pylori was high in this group (approximately 32%). From our data, we suggest that communitywide fecal-oral spread of H. pylori may be of limited importance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Antibodies, Bacterial / blood
  • Child
  • Child, Preschool
  • China / epidemiology
  • Feces / microbiology
  • Helicobacter Infections / epidemiology*
  • Helicobacter Infections / transmission*
  • Helicobacter pylori*
  • Hepatitis A / epidemiology*
  • Hepatitis A / transmission*
  • Humans
  • Immunoglobulin G / blood
  • Infant
  • Middle Aged
  • Mouth
  • Odds Ratio
  • Prevalence
  • Rural Population
  • Urban Population

Substances

  • Antibodies, Bacterial
  • Immunoglobulin G