The results of therapy with a combination of trimethoprim and sulfamethoxazole in 30 brucellosis patients are described. Clinical improvement and apyrexia were achieved in an average of 5 days. Duration of treatment was at least 3 weeks. No success was obtained with the drug in 2 patients while 4 relapsed during the observation period of 2-12 months. Significant side effects were not observed. The results are compared with similar publications.