Role of steroid hormones in potentiating transformation of cervical cells by human papillomaviruses

Trends Microbiol. 1994 Jul;2(7):229-34. doi: 10.1016/0966-842x(94)90627-0.

Abstract

Human papillomaviruses (HPVs) are etiologically involved in cervical neoplasia, and epidemiological evidence suggests that steroid hormones can increase the risk of this cancer in HPV-infected women. Steroids can interact with hormone-response elements in the viral long control region, enhancing HPV transcription and resulting in transformation of cervical cells. Subsequent malignant progression may involve virus-induced chromosomal instability, facilitating viral DNA integration and deregulation of gene expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Viral / drug effects*
  • Dexamethasone / adverse effects
  • Dexamethasone / toxicity
  • Female
  • Humans
  • Models, Biological
  • Papillomaviridae / drug effects
  • Papillomaviridae / pathogenicity*
  • Papillomavirus Infections / virology*
  • Progesterone / adverse effects
  • Progesterone / toxicity
  • Steroids / adverse effects*
  • Steroids / toxicity*
  • Tumor Virus Infections*
  • Uterine Cervical Neoplasms / virology*

Substances

  • Steroids
  • Progesterone
  • Dexamethasone