The reliability of highly elevated CA 19-9 levels

Dis Markers. 1993 Dec;11(5-6):275-8. doi: 10.1155/1993/234238.

Abstract

CA 19-9 is used as a tumour marker of the upper gastrointestinal tract. However, extremely elevated CA 19-9 levels are found also in patients with benign diseases. Cholestasis was present in 97.1% of patients with high elevated CA 19-9, independent of their primary disease. 50% of patients with non-malignant diseases and increased CA 19-9 levels showed liver cirrhosis, cholecystitis, pancreatitis and/or hepatitis. In 8.8% no explanation was found for the extremely high CA 19-9 level. The results provide evidence of different factors influencing the CA 19-9 level.

MeSH terms

  • Antigens, Tumor-Associated, Carbohydrate / blood*
  • Bilirubin / blood
  • Biomarkers, Tumor / blood*
  • Cholecystitis / immunology
  • Colonic Neoplasms / immunology
  • False Positive Reactions
  • Hepatitis / immunology
  • Humans
  • Liver Cirrhosis / immunology
  • Pancreatic Neoplasms / immunology
  • Pancreatitis / immunology
  • Rectal Neoplasms / immunology
  • Reference Values
  • Stomach Neoplasms / immunology

Substances

  • Antigens, Tumor-Associated, Carbohydrate
  • Biomarkers, Tumor
  • Bilirubin