Studies on the metabolism of benzo[a]pyrene and dose-dependent differences in the mutagenic profile of its ultimate carcinogenic metabolite

Drug Metab Rev. 1994;26(1-2):125-63. doi: 10.3109/03602539409029788.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide / metabolism
  • 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide / toxicity*
  • Animals
  • Base Sequence
  • Benzo(a)pyrene / metabolism*
  • Benzo(a)pyrene / toxicity
  • Biotransformation
  • Cell Line
  • Dose-Response Relationship, Drug
  • Humans
  • Liver / drug effects
  • Liver / metabolism
  • Molecular Sequence Data
  • Mutagenesis
  • Mutagens*

Substances

  • Mutagens
  • Benzo(a)pyrene
  • 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide