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A Novel Dodecadepsipeptide, Cereulide, Isolated From Bacillus Cereus Causes Vacuole Formation in HEp-2 Cells

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A Novel Dodecadepsipeptide, Cereulide, Isolated From Bacillus Cereus Causes Vacuole Formation in HEp-2 Cells

N Agata et al. FEMS Microbiol Lett.

Abstract

A HEp-2 cell-vacuolation factor was extracted and purified from the culture supernatant of a Bacillus cereus strain which caused emetic-syndrome food poisoning. The final preparation was chemically pure, and the toxin was named as cereulide. Mass spectrometry, NMR studies and chemical degradation revealed that the cereulide is a cyclic dodecadepsipeptide, (D-O-Leu-D-Ala-L-O-Val-L-Val)3, which is closely related to the potassium ionophore, valinomycin.

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