Increased c-fos expression in nucleus of the solitary tract correlated with conditioned taste aversion to sucrose in rats

Neurosci Lett. 1994 May 19;172(1-2):1-5. doi: 10.1016/0304-3940(94)90648-3.

Abstract

The pattern of neuronal activation in the rat nucleus of the solitary tract (NTS) in response to a standard gustatory stimulus was examined using c-Fos-like immunoreactivity (c-FLI) before and after conditioned taste aversion (CTA) formation. While unconditioned oral infusions of sucrose solution did not induce c-FLI in the NTS, after three pairings of sucrose with lithium chloride injections, sucrose induced c-FLI in the medial intermediate NTS 1 h after oral infusion. Extinction of the CTA by repeated infusions of sucrose alone reversed the induction of c-FLI.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Avoidance Learning / drug effects
  • Avoidance Learning / physiology*
  • Gene Expression / drug effects*
  • Genes, fos / drug effects*
  • Lithium Chloride / pharmacology
  • Male
  • Medulla Oblongata / physiology
  • Rats
  • Solitary Nucleus / drug effects
  • Solitary Nucleus / physiology*
  • Sucrose / pharmacology
  • Taste / drug effects
  • Taste / physiology*

Substances

  • Sucrose
  • Lithium Chloride