CD27: marker and mediator of T-cell activation?

Immunol Today. 1994 Jul;15(7):307-11. doi: 10.1016/0167-5699(94)90077-9.


CD27 is a lymphocyte-specific member of the tumour necrosis factor receptor (TNF-R) family, expression of which is tightly regulated during T-cell ontogeny. Recently, the ligand for CD27 was identified and was shown to be identical to CD70, a novel member of the TNF family. Functional experiments show that the interaction between CD27 and its ligand generates a co-stimulatory signal for T-cell activation. Here, Rogier Hintzen and colleagues integrate the phenotypic and functional data available on CD27 and its ligand, and propose a role for CD27 in the amplification of T-cell responses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD*
  • Biomarkers
  • CD27 Ligand
  • Humans
  • Ligands
  • Lymphocyte Activation / immunology*
  • Membrane Proteins / physiology
  • Receptors, Tumor Necrosis Factor / physiology
  • T-Lymphocytes / immunology*
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 / physiology*


  • Antigens, CD
  • Biomarkers
  • CD27 Ligand
  • CD70 protein, human
  • Ligands
  • Membrane Proteins
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor Receptor Superfamily, Member 7