Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally conserved residues common to Id proteins

Biochim Biophys Acta. 1994 Sep 13;1219(1):160-2. doi: 10.1016/0167-4781(94)90261-5.

Abstract

We have determined the cDNA sequence encoding a 154 amino acid human Id-1 helix-loop-helix protein. Comparison with the amino acid sequences of human and mouse Id-2 and Id-3 proteins, reveals conservation/divergence of several residues in the helix-loop-helix domain known to be important for heterodimerisation, together with a common casein kinase II phosphorylation site.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Casein Kinase II
  • Conserved Sequence
  • DNA, Complementary / genetics
  • DNA-Binding Proteins / genetics*
  • Helix-Loop-Helix Motifs*
  • Humans
  • Inhibitor of Differentiation Protein 1
  • Molecular Sequence Data
  • Phosphorylation
  • Protein Serine-Threonine Kinases / metabolism
  • Repressor Proteins*
  • Sequence Homology, Amino Acid
  • Transcription Factors*

Substances

  • DNA, Complementary
  • DNA-Binding Proteins
  • ID1 protein, human
  • Inhibitor of Differentiation Protein 1
  • Repressor Proteins
  • Transcription Factors
  • Casein Kinase II
  • Protein Serine-Threonine Kinases

Associated data

  • GENBANK/X77956