Effect of hydrochlorothiazide and indomethacin treatment on renal function in nephrogenic diabetes insipidus

Acta Paediatr. 1994 May;83(5):522-5. doi: 10.1111/j.1651-2227.1994.tb13072.x.


The purpose of this study was to investigate the effects of treatment with hydrochlorothiazide and hydrochlorothiazide and indomethacin combined on renal function in four boys, two with nephrogenic diabetes insipidus and two with partial nephrogenic diabetes insipidus using the clearances of inulin and para-aminohippuric acid under water diuresis and lithium clearance. Hydrochlorothiazide reduced urine flow and lithium clearance. These effects were further potentiated by addition of indomethacin. No consistent effects on renal plasma flow or glomerular filtration rate were found. It is concluded that treatment with hydrochlorothiazide alone and hydrochlorothiazide and indomethacin combined reduces urine flow in nephrogenic diabetes insipidus by increasing proximal tubular reabsorption of sodium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Diabetes Insipidus / drug therapy
  • Diabetes Insipidus / physiopathology*
  • Drug Therapy, Combination
  • Humans
  • Hydrochlorothiazide / pharmacology*
  • Hydrochlorothiazide / therapeutic use
  • Indomethacin / pharmacology*
  • Indomethacin / therapeutic use
  • Kidney / drug effects*
  • Kidney / physiopathology
  • Kidney Function Tests
  • Kidney Tubules, Proximal / metabolism
  • Lithium / metabolism
  • Male
  • Sodium / metabolism


  • Hydrochlorothiazide
  • Lithium
  • Sodium
  • Indomethacin