The role of cell-mediated immunity in candidiasis

Trends Microbiol. 1994 Jun;2(6):202-6. doi: 10.1016/0966-842x(94)90112-i.


Clinical observations and animal models show that cell-mediated immunity (CMI) is an important host defense mechanism against Candida albicans infections. In HIV-infected patients, a switch from TH1- to TH2-type CMI responses correlates with the progression to AIDS, and may also increase susceptibility to mucosal candidiasis.

Publication types

  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / immunology
  • Animals
  • Candidiasis / immunology*
  • Candidiasis, Vulvovaginal / immunology
  • Disease Models, Animal
  • Female
  • Gastroenteritis / immunology
  • Humans
  • Immunity, Cellular / physiology*
  • Mice
  • Mice, SCID