SPECT for differential diagnosis of dementia and correlation of rCBF with cognitive impairment

Can J Neurol Sci. 1994 May;21(2):104-11. doi: 10.1017/s0317167100049015.


99mTc-HM-PAO single photon emission computed tomography (SPECT) was used to image 30 patients referred for the assessment of dementia. SPECT images revealed various patterns of regional cerebral perfusion (rCBF) in the subgroups of patients with the clinical diagnoses of Alzheimer's disease (AD, n = 14), Pick's disease (n = 1), and multi-infarct dementia (n = 7). In three patients, SPECT clarified the clinical differential diagnostic possibilities. Using a relative rCBF quantification technique, the relationship between specific cognitive impairments and rCBF in the AD patients was determined. There was a significant correlation between language impairment and left hemisphere hypoperfusion, whereas, apraxia correlated with hypoperfusion in the left parietal region. Thus, HM-PAO SPECT is useful as an aid in the differential diagnosis of dementia and the technique of relative rCBF quantification with SPECT may contribute to the understanding of the clinico-anatomical relations of cognitive deficits in dementia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / diagnostic imaging*
  • Alzheimer Disease / physiopathology
  • Brain / blood supply
  • Brain / diagnostic imaging*
  • Cerebrovascular Circulation*
  • Cognition Disorders / diagnostic imaging
  • Cognition Disorders / physiopathology*
  • Dementia / diagnostic imaging*
  • Dementia / physiopathology
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Middle Aged
  • Organotechnetium Compounds*
  • Oximes*
  • Regional Blood Flow*
  • Technetium Tc 99m Exametazime
  • Tomography, Emission-Computed, Single-Photon*
  • Tomography, X-Ray Computed


  • Organotechnetium Compounds
  • Oximes
  • Technetium Tc 99m Exametazime