Neonatal portal vein thrombosis successfully treated by regional streptokinase infusion

Eur J Pediatr. 1994 Jun;153(6):456-9. doi: 10.1007/BF01983412.


We report a case of portal vein thrombosis (PVT) in a term neonate following an exchange transfusion through an umbilical vein catheter which was left in situ for 16 h after the transfusion. The baby made a complete recovery after successful thrombolysis with regional streptokinase infusion. To our knowledge, this is the first reported case of a PVT following an indwelling portal venous catheter left in situ with complete resolution following thrombolysis with regional streptokinase infusion.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Infant, Newborn
  • Infusions, Intra-Arterial
  • Male
  • Portal Vein*
  • Streptokinase / administration & dosage
  • Streptokinase / therapeutic use*
  • Thrombolytic Therapy*
  • Thrombosis / drug therapy*


  • Streptokinase