Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCNJ3): localization to chromosome 2 and identification of a simple tandem repeat polymorphism

Genomics. 1994 May 1;21(1):254-6. doi: 10.1006/geno.1994.1253.

Abstract

The gene encoding the human G-protein-coupled inwardly rectifying potassium channel designated GIRK1 (gene symbol, KCNJ3) was mapped to chromosome 2 by analyzing its segregation in a panel of human-hamster somatic cell hybrids. This assignment was confirmed by fluorescence in situ hybridization to metaphase chromosomes, and the gene was further localized to band 2q24.1. A highly informative simple tandem repeat DNA polymorphism of the form (CA)n was identified and used to localize KCNJ3 within the genetic map of the long arm of chromosome 2.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 2*
  • Cricetinae
  • GTP-Binding Proteins
  • Genes
  • Humans
  • Hybrid Cells
  • In Situ Hybridization, Fluorescence
  • Lod Score
  • Male
  • Molecular Sequence Data
  • Polymorphism, Genetic*
  • Potassium Channels / genetics*
  • Receptors, Muscarinic / genetics*
  • Repetitive Sequences, Nucleic Acid*

Substances

  • Potassium Channels
  • Receptors, Muscarinic
  • GTP-Binding Proteins

Associated data

  • GENBANK/U07918