During a study performed to estimate the prevalence and evolution of ophthalmologic symptoms in Graves' disease, we examined 85 patients suffering from diffuse hyperfunctional goiter, which was recently discovered. Forty-seven of these patients came back to the one year ophthalmologic control examination. The patients classed 1 in the Nospecs at first examination rarely remained in the same class either worsening or ameliorating. The worsening or amelioration were independent from the treatment employed for hyperthyroidism and from the results of this treatment. The patients classed 0 in the Nospecs mostly remained in the same class. The patients in which first examination discovered more severe signs and especially inflammatory signs (eyelid oedema for example) should be carefully followed up.