The ancient regulatory-protein family of WD-repeat proteins

Nature. 1994 Sep 22;371(6495):297-300. doi: 10.1038/371297a0.


WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion. Here we define the common features of the repeating units, and criteria for grouping such proteins into functional subfamilies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • GTP-Binding Proteins / chemistry
  • Humans
  • Molecular Sequence Data
  • Proteins / chemistry*
  • Proteins / classification
  • Proteins / physiology
  • Repetitive Sequences, Nucleic Acid*
  • Sequence Alignment
  • Transducin / chemistry
  • beta-Transducin Repeat-Containing Proteins


  • BTRC protein, human
  • Proteins
  • beta-Transducin Repeat-Containing Proteins
  • GTP-Binding Proteins
  • Transducin