The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study in Finland

Nutr Rev. 1994 Jul;52(7):242-5. doi: 10.1111/j.1753-4887.1994.tb01430.x.


The U.S. National Cancer Institute and the Finnish National Public Institute jointly sponsored a large double-blind, placebo-controlled primary-prevention trial to examine the effects of vitamin E and beta-carotene supplementation on reducing the incidence of lung cancers in male smokers, ages 50-69 years. Supplementation did not result in a significant reduction in lung cancer, and a higher incidence of lung cancer was observed in the group receiving beta-carotene. These results should be examined within the context of the population studied before they are cited as definitive.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Carotenoids / therapeutic use*
  • Cohort Studies
  • Double-Blind Method
  • Finland / epidemiology
  • Follow-Up Studies
  • Humans
  • Lung Neoplasms / epidemiology
  • Lung Neoplasms / etiology
  • Lung Neoplasms / prevention & control*
  • Male
  • Middle Aged
  • Registries
  • Smoking / adverse effects
  • Vitamin E / therapeutic use*
  • beta Carotene


  • beta Carotene
  • Vitamin E
  • Carotenoids