Initial clinical experience in MR imaging of the brain with a fast fluid-attenuated inversion-recovery pulse sequence

Radiology. 1994 Oct;193(1):173-80. doi: 10.1148/radiology.193.1.8090888.


Purpose: To evaluate fast fluid-attenuated inversion-recovery (FLAIR) technique for imaging brain abnormalities.

Materials and methods: A fast FLAIR sequence was developed that provided 36 5-mm contiguous sections in 5 minutes 8 seconds. Resulting images were compared with dual-echo T2-weighted spin-echo images of 41 consecutive patients with brain abnormalities.

Results: Contrast and contrast-to-noise ratios (C/Ns) (for contrast between the lesion and background and between the lesion and cerebrospinal fluid) for fast FLAIR exceeded the corresponding values for T2-weighted spin-echo images for all but the second-echo lesion-to-background C/N. Fast FLAIR provided equivalent or greater overall lesion conspicuity and enabled greater lesion detection in 98% and 100%, respectively, of the evaluations. Fast FLAIR images more often had image artifact, but this did not interfere with image interpretation in a significantly (P < or = .05) greater number of evaluations.

Conclusion: Fast FLAIR provides images that are superior to proton-density- and T2-weighted images for many image quality criteria.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Artifacts*
  • Brain / pathology*
  • Brain Diseases / diagnosis*
  • Humans
  • Image Enhancement / methods
  • Magnetic Resonance Imaging / methods*
  • Middle Aged
  • Time Factors