Intracranial vascular stenosis and occlusion: diagnostic accuracy of three-dimensional, Fourier transform, time-of-flight MR angiography

Radiology. 1994 Oct;193(1):187-93. doi: 10.1148/radiology.193.1.8090890.


Purpose: To assess the accuracy of three-dimensional, Fourier transform, time-of-flight magnetic resonance (MR) angiography in the detection of intracranial steno-occlusive diseases.

Materials and methods: One hundred thirty-one patients (62 male and 69 female patients, aged 6-77 years [mean, 53 years 8 months]) underwent MR and conventional angiography for evaluation of possible intracranial vascular disease. A total of 502 arteries were assessed. Eight projections and a collapsed image postprocessed by means of a maximum-intensity projection algorithm were reviewed by five observers in a blinded manner, with conventional angiography as the standard.

Results: A total of 32 steno-occlusive lesions were available for review. Receiver operating characteristic analysis from the pooled data revealed overall sensitivities of 85% and 88% and specificities of 96% and 97% for the internal carotid artery and the middle cerebral artery, respectively.

Conclusion: MR angiography is useful as the primary diagnostic tool for evaluating suspected intracranial steno-occlusive disease.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Carotid Artery, Internal / pathology
  • Carotid Stenosis / diagnosis*
  • Carotid Stenosis / diagnostic imaging
  • Carotid Stenosis / epidemiology
  • Cerebral Angiography
  • Cerebral Arterial Diseases / diagnosis*
  • Cerebral Arterial Diseases / diagnostic imaging
  • Cerebral Arterial Diseases / epidemiology
  • Cerebral Arteries / pathology
  • Female
  • Fourier Analysis
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Observer Variation
  • ROC Curve
  • Retrospective Studies
  • Sensitivity and Specificity