Synovial-fluid D-lactic acid in bacterial and other acute joint effusions

Scand J Rheumatol. 1994;23(4):203-5. doi: 10.3109/03009749409103061.


The use of D-lactic acid in differential diagnosis of bacterial arthritis was evaluated in a prospective study. The concentration of D-lactic acid was determined by the enzymatic UV-method in sixty-eight synovial fluids (SF) and in twenty four sera from adult patients with acute knee effusion. High concentrations of D-lactic acid (> 0.15 mmol/l) were measured most frequently in SF from bacterial arthritis, but also in individual culture-negative SF samples from patients with inflammatory culture-negative joint effusions with and without identified history of infections. Determination of SF D-lactic acid is not useful in differential diagnosis of bacterial arthritis.

MeSH terms

  • Arthritis, Infectious* / blood
  • Diagnosis, Differential
  • Humans
  • Lactates / analysis*
  • Lactates / blood
  • Lactic Acid
  • Prospective Studies
  • Synovial Fluid / chemistry*


  • Lactates
  • Lactic Acid