Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 265 (5181), 2088-90

Localization of a Breast Cancer Susceptibility Gene, BRCA2, to Chromosome 13q12-13

Affiliations

Localization of a Breast Cancer Susceptibility Gene, BRCA2, to Chromosome 13q12-13

R Wooster et al. Science.

Abstract

A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.

Similar articles

See all similar articles

Cited by 353 PubMed Central articles

See all "Cited by" articles

Publication types

Substances

Feedback