The putative cell receptors for hepatitis B virus (HBV), annexin V, and apolipoprotein H, bind to lipid components of HBV

Virology. 1994 Oct;204(1):475-7. doi: 10.1006/viro.1994.1558.


Annexin V and apolipoprotein H, reported to bind hepatitis B surface antigen (HBsAg) and presumed to react specifically with the HBsAg S protein and to play an important role in initiation of infection by hepatitis B virus, did not bind to delipidated HBsAg (dlHBsAg). Binding activity was restored by adding lipids to dlHBsAg. These results are consistent with the established affinity of annexin V and apolipoprotein H for lipids.

MeSH terms

  • Annexin A5 / metabolism*
  • Apolipoproteins / metabolism*
  • Glycoproteins / metabolism*
  • Hepatitis B Surface Antigens / metabolism
  • Hepatitis B virus / metabolism*
  • Kinetics
  • Lipid Metabolism
  • Lipoproteins, LDL / metabolism
  • Phosphatidylcholines / metabolism
  • Phosphatidylserines / metabolism
  • Receptors, Antigen / metabolism*
  • beta 2-Glycoprotein I


  • Annexin A5
  • Apolipoproteins
  • Glycoproteins
  • Hepatitis B Surface Antigens
  • Lipoproteins, LDL
  • Phosphatidylcholines
  • Phosphatidylserines
  • Receptors, Antigen
  • beta 2-Glycoprotein I
  • hepatitis B surface antigen receptor