Effect of calcium citrate supplementation on urinary calcium oxalate saturation in female stone formers: implications for prevention of osteoporosis

Am J Clin Nutr. 1994 Oct;60(4):592-6. doi: 10.1093/ajcn/60.4.592.

Abstract

In 14 women aged 37-68 y with a history of renal calcium calculi, bone densities were 12.0% below those of age-matched control subjects at the L2-4 lumbar spine (P = 0.007) and 6.4% less at the femoral neck (P = 0.095). A low-oxalate diet was supplemented with 1 g Ca/d as citrate. In 6 mo, plasma 1,25(OH)2D concentrations fell from 53.2 +/- 18.8 to 41.9 +/- 15.2 ng/L (P = 0.02) and parathyroid hormone from 39.1 +/- 17.0 to 30.8 +/- 12.5 ng/L (P = 0.02). Calcium oxalate saturation was 2.15 +/- 1.38 at baseline, 2.27 +/- 1.00 at 1 mo, and 2.06 +/- 1.57 at 6 mo. The increase in urinary calcium at 1 mo from 4.411 +/- 1.87 to 6.514 +/- 2.82 mmol/24 h (P = 0.01) was offset by a parallel increase in citrate excretion from 2.909 +/- 1.45 to 3.455 +/- 1.34 mmol/24 h (P = 0.03). Calcium citrate supplementation did not increase the lithogenicity of the women in this protocol.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Bone Density
  • Calcium / urine
  • Calcium Oxalate / urine*
  • Citrates / adverse effects*
  • Citrates / therapeutic use
  • Citrates / urine
  • Citric Acid
  • Female
  • Humans
  • Kidney Calculi / chemically induced
  • Kidney Calculi / urine*
  • Middle Aged
  • Osteoporosis, Postmenopausal / prevention & control*
  • Time Factors

Substances

  • Citrates
  • Calcium Oxalate
  • Citric Acid
  • Calcium