Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 203 (2), 1090-5

Highly Frequent Homozygous Deletion of the p16 Gene in Esophageal Cancer Cell Lines

Affiliations

Highly Frequent Homozygous Deletion of the p16 Gene in Esophageal Cancer Cell Lines

H Igaki et al. Biochem Biophys Res Commun.

Abstract

To study the involvement of the p16 tumor suppressor gene in esophageal cancer development, we examined homozygous deletion of the p16 gene in 13 human esophageal cancer cell lines and 9 gastric cancer cell lines, in which some of genetic alterations have already been characterized. By Southern blot analysis, homozygous deletion was observed in 12 out of the 13 esophageal cancer cell lines (92%), in 2 out of a total of 9 gastric cancer cell lines (22%). It was also found that the p16 gene loss, cyclin D1 amplification and p53 gene mutations occurred independently in these cell lines. These findings suggest that loss or mutations of the p16 gene are involved in most esophageal cancers and that mutation of this gene plays a critical role in the development of esophageal cancer.

Similar articles

See all similar articles

Cited by 9 PubMed Central articles

See all "Cited by" articles

Publication types

Feedback