Primary central nervous system involvement of the so called 'peripheral T-cell lymphoma'. Report of a case and review of the literature

J Neurooncol. 1993 Jun;16(3):235-42. doi: 10.1007/BF01057040.

Abstract

Primary central nervous system (CNS) involvement of non-Hodgkin's lymphoma is uncommon and a vast majority of reported cases are of B-cell origin. We present a 52-year-old woman with primary peripheral T-cell lymphoma of the brain. Immunostaining of paraffin-embedded sections proved tumor cells to be positive for T-cell markers MT1 and UCHL1, and negative for B-cell markers MB1, and 4KB5. Radiotherapy combined with steroid therapy rendered neurologic recovery and complete tumor remission confirmed by computed tomography and magnetic resonance imaging. From a review of documented 19 cases of primary CNS T-cell lymphoma including the present case, this disease is characterized by poor prognosis among CNS lymphomas.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Astrocytoma / diagnosis
  • Basal Ganglia*
  • Biopsy
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / mortality
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / radiotherapy
  • Combined Modality Therapy
  • Dexamethasone / therapeutic use
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunophenotyping
  • Life Tables
  • Lymphoma, Non-Hodgkin / diagnosis
  • Lymphoma, Non-Hodgkin / drug therapy
  • Lymphoma, Non-Hodgkin / pathology*
  • Lymphoma, Non-Hodgkin / radiotherapy
  • Lymphoma, T-Cell / classification*
  • Lymphoma, T-Cell / pathology
  • Lymphoma, T-Cell, Peripheral / diagnosis
  • Lymphoma, T-Cell, Peripheral / mortality
  • Lymphoma, T-Cell, Peripheral / pathology*
  • Lymphoma, T-Cell, Peripheral / radiotherapy
  • Lymphoma, T-Cell, Peripheral / therapy
  • Methotrexate / administration & dosage
  • Methylprednisolone / therapeutic use
  • Middle Aged
  • Survival Analysis
  • Vincristine / administration & dosage

Substances

  • Vincristine
  • Dexamethasone
  • Methylprednisolone
  • Methotrexate