Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies

Lancet. 1993 Jan 2;341(8836):21-2. doi: 10.1016/0140-6736(93)92485-c.


We describe three patients with known or suspected small-cell lung cancer (SCLC), paraneoplastic neurological syndromes, and antineuronal antibodies who had unusually benign clinical courses. One patient survived 8 years free of disease and was positive for the anti-Hu antibody. A second patient survived 6 years after spontaneous tumour regression and had an atypical antineuronal antibody. A third patient with both the anti-Hu and atypical antineuronal antibody had spontaneous regression of a lung mass. All three patients had a subacute sensory neuropathy. Since paraneoplastic antineuronal antibodies also bind to tumour cells, these cases suggest that some (paraneoplastic) neurological syndromes without identifiable tumour may result from immune-mediated eradication of tumour cells.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Antibodies / analysis*
  • Carcinoma, Small Cell / immunology*
  • Humans
  • Lung Neoplasms / immunology*
  • Male
  • Middle Aged
  • Neoplasm Regression, Spontaneous / immunology*
  • Nervous System Diseases / immunology
  • Neurons, Afferent / immunology*
  • Paraneoplastic Syndromes / immunology*


  • Antibodies