Measles virus-induced changes in leukocyte function antigen 1 expression and leukocyte aggregation: possible role in measles virus pathogenesis

J Virol. 1993 Feb;67(2):1075-9. doi: 10.1128/JVI.67.2.1075-1079.1993.


Measles virus (MV) infection of U937 cell or peripheral blood leukocyte cultures was shown to induce changes in the expression of leukocyte function antigen 1 (LFA-1) and cause marked aggregation of these cells. Addition of selected monoclonal antibodies specific for LFA-1 epitopes that did not neutralize MV in standard neutralization assays were found to block both virus-induced leukocyte aggregation and virus dissemination. These data suggest that MV modulation of LFA-1 expression on leukocytes may be an important step in MV pathogenesis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Monoclonal / pharmacology
  • Antigens, CD / biosynthesis*
  • CD18 Antigens
  • Cell Aggregation / drug effects
  • Culture Media / pharmacology
  • Flow Cytometry
  • Gene Expression Regulation
  • Humans
  • Integrins / drug effects
  • Leukocytes, Mononuclear / microbiology*
  • Lymphocyte Function-Associated Antigen-1 / biosynthesis*
  • Measles / etiology*
  • Measles virus / physiology*


  • Antibodies, Monoclonal
  • Antigens, CD
  • CD18 Antigens
  • Culture Media
  • Integrins
  • Lymphocyte Function-Associated Antigen-1