Magnetic resonance imaging of spinal cord in multiple sclerosis by fluid-attenuated inversion recovery

Lancet. 1993 Mar 6;341(8845):593-4. doi: 10.1016/0140-6736(93)90353-i.


Magnetic resonance imaging examination of the upper spinal cord was done in sixteen adult patients with clinically definite multiple sclerosis (MS) by T2 weighted fluid attenuated inversion recovery (FLAIR) scanning in which the signal from cerebrospinal fluid was suppressed. These scans were compared with matched images obtained with conventional T1 and T2 weighted pulse sequences (including contrast enhancement). 6 lesions (five patients) were seen with the conventional scans and 37 lesions (fourteen patients) were seen with the FLAIR scans. The FLAIR sequence considerably improves the ability of MRI to demonstrate spinal involvement in MS.

MeSH terms

  • Adult
  • Artifacts
  • Cerebrospinal Fluid
  • Evaluation Studies as Topic
  • Female
  • Humans
  • Image Enhancement / methods*
  • Image Enhancement / standards
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Imaging / standards
  • Male
  • Middle Aged
  • Multiple Sclerosis / cerebrospinal fluid
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / epidemiology
  • Sensitivity and Specificity
  • Spinal Diseases / cerebrospinal fluid
  • Spinal Diseases / diagnosis*
  • Spinal Diseases / epidemiology